KMID : 0882420080740040445
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Korean Journal of Medicine 2008 Volume.74 No. 4 p.445 ~ p.450
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Air-leakage syndrome after allogeneic peripheral blood stem cell transplantation from unrelated donor
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Kim Si-Hyun
Shin Joo-Young Hwang Hyeon-Seok Kim Dae-Joon Kim Hee-Je Min Woo-Sung Kim Chun-Choo
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Abstract
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Bronchiolitis obliterans, a late, non-infectious pulmonary complication of bone marrow transplantation (BMT), is an obstructive airway disease associated with chronic graft-versus-host disease (cGVHD). We report a rare case of air-leakage syndrome including pneumothoraces, pneumomediastinum, and subcutaneous emphysema with bronchiolitis obliterans after allogeneic peripheral blood stem cell transplantation (PBSCT) from an unrelated donor. The pathogenesis of air-leakage syndrome is not fully understood, and its management has not yet been established. This patient was treated with high-concentration oxygen, tube thoracostomy, percutaneous drainage with a pigtail catheter to relieve the tension pneumomediastinum, and mechanical ventilatory support. The patient has now recovered and is being followed on an outpatient basis.
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KEYWORD
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Air-leakage syndrome, Bronchiolitis obliterans, Peripheral blood stem cell transplantation
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